Dangers of Stevia, Supplements, Soil Mineral Depletion | LIVE CALL: THRR015

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This episode of The Healthy Rebellion Radio is sponsored by Perfect Keto. Perfect Keto makes eating keto easier. Perfect Keto provides clean low-carb bars, nut butters, and supplements, and the best keto recipes and info so you can keto with confidence. Go to http://perfectketo.com/rebellion10 and use code REBELLION10 for $10 off orders of $40 or more.

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Submit your questions for the podcast here

Show Notes:

News topic du jour: Silicon Ranch partners with organic livestock farm in Georgia for solar sheep grazing

1. Supplementing for soil depletion of minerals [11:35]

2. Supplements Affecting Exercise Adaptation [17:50]

3. Ketosis [28:55]

4. Behavior Change [48:39]

5. Dangers of Stevia [54:20]
from Nate
Hi Robb and Nicki,
Huge fan of the show and format.
Do you see any dangers in consuming pure stevia? Powder or liquid. Other than the obvious danger of it potentially making you crave more sweeter foods.
Have you read about any credible downsides to it that would concern you?
I love the stuff, it helps me on my keto diet and I just want to make sure its cool to keep consuming in moderation (quarter to half tsp maybe a day).
Thanks again for being an unbiased source of truth in this crazy landscape.


Nicki: Its time to make your health an act of rebellion. Were tackling personalized nutrition, metabolic flexibility, resilient aging, and answering your diet and lifestyle questions. This is the only show with the bold aim to help 1 million people liberate themselves from the sick care system.

Nicki: Youre listening to The Healthy Rebellion Radio. The contents of this show are for entertainment and educational purposes only. Nothing in this podcast should be considered medical advice. Please consult your licensed and credentialed functional medicine practitioner before embarking on any health, dietary, or fitness changes. Warning Robb gets passionate, hes been known to use the occasion expletive. If foul language is not your thing. If it gets your britches in a bunch, well theres always Disney+.

Robb: Whats up wife?

Nicki: Its time for another episode.

Robb: Its.

Nicki: Its time-

Robb: Time.

Nicki: For another episode of The Healthy Rebellion Radio. Welcome everyone to our crazy little moment in time here. It is a nice day here in New Braunfels, Texas though.

Robb: It is pretty nice. Sun is coming out. Its going to be nice and warm, so yeah.

Nicki: We had a lot of rain last night and its looking like the fog is burning off and its a good day.

Robb: Mats are being delivered to Straight Blast Gym Texas today, which this podcast will air a bit after this, but very excited for jiu-jitsu to get going.

Nicki: Absolutely. What do you have for us today with your news topic?

Robb: Oh, the news topic. The title is Silicon Ranch partners with organic livestock farm in Georgia for solar sheep grazing. So todays topic is a bit of a sustainability regenerative ag story, but its pretty cool. White Oak Pastures pastures has partnered with this outfit Silicon Ranch, which is basically one of these big solar farm outfits and whats emerging out of this story is the potential upsides of solar energy can be welded to another upside of solar energy, which is grazing animals.

Robb: People kind of forget the whole solar powered feature of pastures and grazing animals and whatnot. But White Oak Pastures has this research that demonstrates that their meat production is a net carbon sink. It has all kinds of beneficial effects on local ecology birds that interestingly the Audubon Society, this is some of this stuff thats really important and Im looking forward to Sacred Cow getting out there both in the film and the book form, but people assume that ranching in animal husbandry is necessarily injurious to the environment.

Robb: But the Audubon Society has been one of the folks that has really embraced the Allan Savory kind of flavor of regenerative ag. So anyway, within this-

Nicki: Because of the impact on the birds.

Robb: Because of the beneficial impact on the birds. People who look at birds and want to protect birds, theyre finding that the habitat is being restored and that animals that were endangered or had not been seen in particular areas for 15 or 20 years are now back in large numbers.

Robb: So this is some of the really important stuff to get out there and to talk about and to have discussions around because theres just a monotone that animals are bad, animal husbandry is bad and that may not be the case. It may in fact be a story of this is one of the only legitimate solutions that we have. And whats interesting is theyre predicting millions and millions of acres globally that will be under use with these solar farms, which is great.

Robb: It has some challenges in and of itself. Solar panels actually have a limited life cycle and the recycling of that stuff is pretty toxic and difficult. So Im optimistic about solar energy, but it is by no means a free lunch in that story. But whats interesting is mixed into that whole process is the opportunity to have vast numbers of grazing animals that maintain those areas and maintain the normal ecology and produce food.

Robb: And so this is something that when people kind of hand wringing about, Oh, how do we feed the world going forward? There are enormous tracks of land that are amenable to nothing but the raising of animals on grass. So this is a great article and it points out kind of an intersection of technology that is arguably 10,000 years old with technology that is 50 years old, photovoltaics and then holistically managed grass eating animals. So cool article, weve got the link for you in the show notes. Please read that. Please share it with people.

Nicki: And we actually interviewed Will Harris of White Oak Pastures as a live interview inside The Healthy Rebellion community and it was amazing and we will be excited to share that interview with yall here in another month or so, but just cant say enough about what he is doing for not only his local economy, but the land and the animals and you just get this amazing, I dont know, richness and just goodness listening to him speak and what hes done over his lifetime with his animal.

Robb: And just a real quick, maybe a highlight on that Will was a very successful conventional meat producer and he said that he was one of the best at it, which interestingly he said was likely why his farmland ended up cratering perhaps the earliest because he had figured out such an extractive process that the grasses were failing, the soil was failing and it wasnt good for him, wasnt good for the animals, wasnt good for the local environment.

Robb: And Wills a good old boy from the South and likes to make money and all the rest of that. But at the same time he started seeing not only an economic kind of brick wall facing him, but also just some stuff that it is kind of moral core he couldnt really deal with. And whats interesting is it was a slow iterative process, but these holistic management practices are what he ended up adopting. And its been both economically successful for him, but then also environmentally its a major, major win.

Robb: So these are the stories that weve got to both critically assess like are they legit? Is what is being claimed here true? Lets be honest about that. But if it is, then we need to be singing this stuff from the rooftops. It cant just be game changers and pea protein all the live long day.

Nicki: Awesome. Already its time for our Healthy Rebellion Radio t-shirt review winner. This one is from, I dont know if its even pronounceable, G-O-U-K-U-G-T, goukugt.

Robb: Goukugt.

Nicki: Thank you for all your positive influence. Thank you Robb and Nicki, Ive been a listener since 2012 and I found paleo to help cure my arthritis. I was 28 and in grad school, which is too young for a chronic illness. I found that the trigger was wheat and Ive been arthritis free since then. Ive always been inspired by your work and my research has steered towards using diet as a therapeutic tool.

Nicki: I study polycystic kidney disease and Ive published two papers this past year on the impact that ketosis and oxalates have on disease progression. I wouldnt have been able to do this without first healing myself so that I could still hold a pipette. Keep doing the great work you do and inspire more out there like myself, Dr. Jacob T. Awesome Dr Jacob T. thank you.

Nicki: Please send us an email to hello@robbwolf.com with your tee shirt size and your mailing address and we will send you a Healthy Rebellion Radio t-shirt.

Robb: Awesome.

Nicki: All right. This episode of The Healthy Rebellion Radio is sponsored by Perfect Keto. Perfect Keto makes eating keto easier. Perfect Keto provides clean, low-carb bars, nut butters and supplements and the best keto recipes and information so that you can keto with confidence. And Robb, we just got a box of their brand new keto birthday cake bar, which is quite good. I normally am not a birthday cake flavor kind of girl.

Robb: Just like youre not a cheese girl.

Nicki: Im not a cheese girl either, but I really liked it.

Robb: You liked it, Sagan liked it. The mouth feel was good. And whats interesting about this stuff too is the girls generally like these things, but theyll do a half of one or one and then theyre done. So its not like that-

Nicki: They want to go back to that.

Robb: Cocaine thing where theyre going to want to like smash the whole box, which I think is of telling.

Nicki: So if you havent checked out their lineup of keto snacks and bars, go to perfectketo.com/rebellion10 and use code REBELLION10 for $10 off orders of $40 or more. And Robb this here is a live call episode.

Robb: Well, right here, Nicki, we have a live espisode.

Nicki: We have a live call, but this might be our last live call, at least for a wee bit.

Robb: Its super fun to be able to ask people additional questions, but the technical challenges of pulling this off were kind of crazy.

Nicki: It was a cool experiment and I think weve really enjoyed it, but heres the challenge that we face when we first go live. And we were using a thing that we can see the people in queue when we first go live, we see theres like five or six callers there, but we dont really have a way to communicate with people to tell them where theyre at in line.

Nicki: And so then well take the first persons question and then by the time were done with the first person question, the other people have hung up because theyre like, they have no idea how long theyre going to have to wait. So theyre like, Oh, screw this. I dont want to sit here for 30 minutes or an hour. So then we answer one question and then were sitting and we have no callers on the line.

Nicki: And so then were waiting and waiting and maybe we get another one. And so its been Weve blocked them. When we did them, we did an hour and a half slot and it was kind of challenging to get our five callers for the show during that hour and a half block because of the way what I just described with-

Robb: We might have 20 people call in but were only able to grab-

Nicki: But then because of how-

Robb: A few of them.

Nicki: So did a little reflection and I think were going to hold off on that until we can come up with a little bit of a better-

Robb: We need a little better technology.

Nicki: System.

Robb: We need a little better system. Itd be fun to do something like this in the future. In The Healthy Rebellion, we are doing some text chats in there which live text chats-

Nicki: Which have been really fun.

Robb: Which had been really fun. So were going to start putting more emphasis on that because thats a great way to interact with people, get some live back and forth, ask those lead on questions. But its much more technologically doable for us at this point.

Nicki: Right. So I guess-

Robb: So for now, this is the last live call.

Nicki: Yep. Until we figure out a way to solve for this, then well be doing our regular Q and A. So you guys can always submit your questions via the website, robbwolf.com and then lets jump into our callers.

Nicki: Hello. Welcome to The Healthy Rebellion Radio caller from seven eight five tell us your name, where youre calling from in your question please.

Ben: Hello, Robb and Nicki. This is Ben from Ruleville.

Nicki: Hey Ben, thanks for your patience.

Ben: Oh, no problem. I have kind of a two part question, a small question then maybe a bigger concept related to it. I wanted to know if you or Robb had any insight on supplementing with fulvic acid or sometimes I think Ayuverdic realm is called shilajit, but its like that black tar substance. But in a broader sense, the reason I ask that is because I have read some stuff on it and started messing around with it myself because what Ive read its there to fill any gaps that were missing from the farming or the current state of agriculture, depleting the minerals from the soil.

Ben: So we used to get a lot of trace minerals from ground root vegetables and things like that, but now were missing that either through agricultural depletion or then the washing and transport of these vegetables or whatever. So I just wanted to hear you guys take on any of that. If its a valuable thing to supplement with or its even an issue we should worry about.

Robb: Oh man. So Im not familiar with that term. There was a substance that Dr. Fred Hatfield ages ago mentioned it sounds like this, and it was called Mumi, M-U-M-I. And it was kind of this tare substance. It was supposed to be really nutrient dense, but I mean, I heard about this in the late 80s early 90s and then I really havent heard anything since then.

Robb: And similar to being able to sing along to like Scooby doo and stuff like that. Its a piece of obscure information that just lodged in my head and I dont know that it has any relevance to today at all. In general supplementation with Foley is a little bit of a tricky story which is kind of separate from just the basic mineral piece.

Robb: Chris Master John has done a pretty interesting look at I guess methylation status and what not and is really kind of arrived at this idea that riboflavin supplementation is kind of the master governor for the whole methylation story for the MTFR gene mutations or gene permutations. On the mineral side it makes sense to me to try to round out our minerals and trace minerals.

Robb: I think that this is where things like sea food and sea vegetables are probably a pretty good plan. It at least in some regards because at a minimum I think that other than adding pollutants to sea water, the mineral composition of the water itself and the critters in it has probably changed less in state, like the less 10,000 and a hundred thousand years then our soil has.

Robb: And so it I dont know that you fully deal with selenium and a few other trace minerals in that context, but I do think that just a real judicious application of sea vegetables and seafood could probably plug a lot of the holes and kind of the deficiencies of a modern agricultural diet.

Robb: I would make the case that this is one of those things that I think its going to take a while to fully vet this out, but when you have meat in particular meat that is produced on a patch of dirt that has really solid holistic management, regenerative farming practices, youre feeding the soil microbiome in a way that those critters are then mining various nutrients out of the soil and putting it into grass.

Robb: And then that goes into the animals and its pretty early. But I think that theres a powerful case to be made that you probably have a better nutrient profile than with the industrial agriculture approach, which is putting synthetic fertilizer in all of the activity is happening right there at the surface of the soil and youre actually kind of destroying that deeper microbial interaction that mines minerals.

Robb: So I think that over the course of time, this is another one of these cases for why regenerative farming is probably going to be really important. I dont know if that entirely answers your question. Thats kind of what Ive got.

Ben: Yeah, no that, yeah. So what has Hatfield was talking about is the same stuff. Its over in Russia and the rocky areas over there, they source it. But no, that answers a lot because thats just something I know we really like to talk about micronutrients a lot. But in with regenerative farming, were focusing a lot on the practices around raising livestock.

Ben: But I know that the whole component as well is the depletion of the ground minerals and how we used to be able to get some of that from those vegetables. And I just was wondering if you had any insight.

Robb: Yeah, I think leaning heavily on regenerative practices and then I do think interim to that. Some things like Mumi maybe could be a way to fill some of that gap. And then I, my sense is also that leaning heavily on ocean derived plant and animal material is a really solid way to kind of plug some of those potential gaps.

Ben: Awesome. That answers it.

Robb: Thanks for hanging in there with us. We had all manner of-

Nicki: Technical diffculties.

Robb: Technical difficulty getting this thing fired back up, so thanks for hanging in there.

Ben: No problem. I appreciate what you guys do so its no problem.

Robb: Awesome. Thanks man.

Nicki: Thanks Ben.

Robb: Take care.

Ben: Yep. See you.

Robb: Bye. Bye.

Nicki: All right, we have a caller from area code three O four area code three O four youre on the line. Please tell us your name, where youre calling from in your question please.

Isaac: Robb and Nicki, how are you doing? This is Isaac. Im calling from Ohio.

Robb: Hey man.

Nicki: Hey man.

Robb: Great to get you.

Isaac: All right, so heres the deal. I beat the odds and I was selected for a very selective race, 100 Mile trail race out in California and last time I did it, I barely made my time goal. So this time Im going to have to look for every optimization out there and I want to get it perfectly right.

Isaac: So the thing thats been on my mind is related to like supplements that may be could backfire and specifically thinking about resveratrol, vitamin C and then other interventions like ice water baths or yoga and Dr Gundrys book Plant Paradox even has me looking skeptically at plants now.

Isaac: So Im wondering if you have any thoughts on spacing, endurance, exercise with certain supplements or whether theres no concern for any of the things that Ive mentioned.

Robb: No, I think that youre really onto something there and we could maybe make the case that this is getting out to the last few percentage points in adaptation. But then again maybe not some of the studies that have been done looking at say like Potassium bicarbonate supplementation in and around say lactate producing exercise.

Robb: People will get a performance bump so long as they dont succumb to the gastric emptying deal of spewing out of both ends with that but the bicarbonates seems to blunt all of that kind of hormetic stress adaptation and we see a similar thing with vitamins in general, vitamin C and so it really its interesting.

Robb: Ive been listening to a lot of podcasts thats a little bit of a tangential thing. I will really try to pull this thing back in, but Ive been listening to a lot of podcasts on just longevity in general, like work from Dr michael Rose and he just makes this case that there might be some real specific supplements that we may be wanting to use once in a while similar to a pharmaceutical, but theres all manner of speculation around things like TA-65 elongating telomeres and different things like that.

Robb: Everybody was geeked out on, you need super high antioxidant intake because reactive oxygen species appear to be a co factor in the aging process. But then what we found is you ended up with immune dem regulation and all this other stuff. And so I guess my point of that is figuring out a way to really optimally fuel your training and kind of periodicing that.

Robb: And so building your robotic base and then honing that edge you with a peaking cycle. And its interesting even on the recovery side, and Ive kind of thought about this and Ive seen some stuff that suggests this, but Pavel Tsatsouline was just on Joe Rogan and he made the point that things like ice water baths, one, it can blunt the adaptation to exercise.

Robb: But then two, what was interesting is that it actually can encourage the body to rely on that process as part of the recovery. And so what actually ends up limiting the total kind of adaptive process that we could get. And if I were to default to anything, it would actually be sauna exposure. And I could make a case on two points for that.

Robb: One, heat shock proteins seem a lot better suited for dealing with the demands of exercise than cold shock proteins. Although theres certainly value to cold shock proteins without a doubt. But then theres also this opportunity to get a legitimate less than tricolor stretch training adaptation from that sauna session.

Robb: So I would and my sense is that post-training sauna does not downregulate that pulsatile inflammatory state. If anything, it enhances it. And again, there may be, could be an argument that perhaps we dont want to do that too often or too much. Im not entirely sure about that. But I think that youre on some really good footing here questioning is ribs near trawl is a concentrated dose vitamin C really going to do you any favors in the context of trying to force a really powerful training adaptation for an event.

Robb: And then maybe during the event thats it. And clearly you have to do some tinkering with this ahead of time, but a buffered vitamin C with the bicarbonate mix that could buffer lactate and keep total pH within perhaps better operating parameters on game day that might be a really viable solution, but youre just going to perhaps test that over time and not really rely on it as training adaptation but more to know how to use it. And then do you exclusively use it on training on game day.

Isaac: Yeah. I mean thats, those are some excellent ideas. Especially I think the sauna is going to be really important for me. But I also like what you said about the periodization, because I think thats a mistake Ive made in the past was doing the same thing too often. So I think mixing it up is probably a good approach.

Robb: Yeah. And I dont know if you followed Zach Bitter, but that guy is really smart on this stuff. And he will admit that theres a lot of individual variation, but some folks its so much simpler. If its like Zack Bitter is carnivore. And its like he never eats plant material and its like, well thats not really true.

Robb: He uses that in a really smart and sophisticated way to kind of goose a specific training adaptation. And then on these days where hes covering a hundred miles in a pretty quick pace. Hes using targeted carbs now hes using a fraction, the amount of carbs that most people would use under similar circumstances but he is absolutely using carbs.

Robb: I dont remember him talking about some things like a buffered vitamin C or bicarbonates to try to deal with that side of kind of the metabolic acidosis. But hes operating at a really sophisticated level with that for sure.

Isaac: Well thats great. I really appreciate it. But let me get greedy and just ask one more follow up.

Robb: Lay it on me.

Isaac: And its on a related note, what are your thoughts on Sulforaphane? Because its another one of those, its not a supplement. Im getting it just from broccoli sprouts. But its the sort of thing where Im wondering could it blunt because its supposedly a powerful antioxidant, may be doing similar things that resveratrol would. So do you have any specific thoughts about broccoli sprouts in Sulforaphane?

Robb: Im confused on it to be honest because theres all this great correlative stuff that suggests its healthy. Is that in the context of just kind of so much of what we see there, it might be preventing some of the deleterious effects of a poor diet and poor lifestyle. So what does that mean in the context of an elite athlete like yourself?

Robb: And Im not entirely sure there. Its interesting. Anything that we call an antioxidant can be a pro oxidant under the right circumstances. So its really a case of relativity there, whether like vitamin C or so many of these things statens function as antioxidants to some degree. So its interesting what falls under that context of like antioxidant.

Robb: What also appears to be happening is some degree of that mito hormetic stress thats occurring with these plant materials. Man, Im not entirely sure what the real deal is there. I mean it seems just the epidemiology would suggest that eating some cruciferous vegetables are generally a pretty good idea. Just this morning I had two people on Instagram messaging.

Robb: These were much shorter races, but a 5K and a 10K two separate people that, but they were like, Hey man, I just had to tell you like listen to the Paul Saladino podcasts have been tinkering with carnivores and they both set and its really intriguing now these are much shorter races than a hundred miles.

Robb: So thats a big deal. But thats really intriguing. Its fascinating to me because theres just a million different ways to tank your performance. Youd have a terrible night of sleep. You could go out and drink a bunch of booze, you could screw up your electrolytes and stuff like that.

Robb: But these folks have shifted, do what appears to be a largely carnivore intake. And like Sean Baker is kind of made the case if youre. So I guess if the story from the carnival or camp is true that the main benefit that vegetables provide is this mito hormetic stress. And then if youre training really hard, youre getting a mito hormetic stress there. Do you need anymore? And I dont know maybe not.

Robb: Maybe you want to save all of that adaptation for just dealing with the exercise and not necessarily plant toxicants. And that sounds like crazy talk, but its plausible. I would put the likelihood maybe a little bit on the low side, but its possible. And again, its just intriguing that people are going from what is generally a pretty Theyre eating clean, theyre kind of paleo, maybe theyre eating keto and then they pull out all plant materials and all of a sudden they get a PR.

Robb: And then I also know for sure there are folks at the flip side of that, that are not doing well with it. So it, and then that begs the question like how are they doing it? What other factors are in there. I do think that for these longer events, like what you were talking about, what Zach Bitter has competed in, theres probably a case to be made for doing things some sort of a starch or glucose polymer or something like that in that context. Awesome, man.

Isaac: Well, hey, thanks a lot. I really appreciate it. Youve given me so much to consider and more generally, I think that you and Nicki help out so many people, so Im just so grateful for the chance to say hello.

Robb: Hey man. Thank you.

Nicki: Thanks Isaac.

Robb: Take care.

Isaac: All right, take care. Bye.

Robb: Okay. Bye, bye.

Nicki: Okay. All right. We have a caller from eight one five. Welcome to The Healthy Rebellion Radio. Please tell us your name, where youre calling from and your question.

Ben: So yeah, my names Ben. Im from the Chicago land area and yeah, I had some questions, comments are about ketosis.

Robb: Lay it on me.

Ben: Okay. So I follow, I dont know if youve heard of a guy named Bart Kay, who hes part of the carnivore scene. And he has some, I mean hes pretty smart. Youve spent some time in academia and he has some ideas about ketosis where he says that He talks about ketosis I think his hypothesis is that ketones are a secondary messenger for a hormone system and your endocrine functioning.

Ben: And his argument is that its not a good idea to be in ketosis all the time. Granted he doesnt really find a level of ketosis that hes talking about and then kind of goes on this if youre doing carnivores, like especially like a version thats probably over a pound of meat a day and maybe with one meal a day youd be doing basically kind of like a daily kind of keto cycling where youre going to be keto for a large part of the day and then-

Robb: Bump out due to the big meal.

Ben: The big meal. When you do that, when you eat all the protein then youre going to be gluconeogenic and then thats I guess kick you out of ketosis enough that its not going to harm your metabolism or your thyroid. And I guess you want him to think that would kind of add to that.

Ben: My experience is, like a couple of weeks ago I was getting hardcore about measuring my ketones and glucose and a thing that was interesting is my ketones were never above like 0.12 but my glucose was always in like 80. I kind of expected that it would be like dipping lower than that. But it wasnt and

Robb: I think I know what youre digging at. Let me jump in here and then you can save me if Im bailing off of a cliff, but its interesting. Ages ago, I mean the mid to late 90s Dr michael Eades was recommending a low carb diet, not necessarily a super high fat diet. Now he wasnt afraid of fat, but he made the case ages ago that he would like to see the glucose thats used by the body primarily come as a consequence of gluconeogenesis out of the liver and mainly from dominating breaking down proteins because it was a super slow steady titration.

Robb: Theres a super high nutrient density attached to it. Theres a high thermic effect. And so whats interesting to me in some ways is in this story of carnivore versus keto or whatever a carnivore diet is its effectively a low carbohydrate diet, but it doesnt necessarily mean that its a low glycogen diet or low glycogen state because of the amount of protein folks are eating.

Robb: I think that we could see reasonable topping off of both muscle and liver glycogen, both from the fat and more specifically the protein. And its really interesting and I honestly dont know whats the real deal is here. I definitely could see the case for transient ketosis being a favorable thing. I think that a little bit of pulsatile exposure to glucose either via kind of hepatic released glucose or some carbohydrate in the diet.

Robb: I can see some arguments from that from kind of like a hormetic stress response kind of perspective and it wouldnt require much to get that. And then there is just a lot of really interesting stuff around potential anti aging benefits of these secondary messengers effects that ketone bodies might play stack inhibition and stuff like that. So I have not followed Barts work super specifically, but Im familiar with kind of the broad brush strokes and I dont take issue with any of it.

Robb: I think that this, a lot of this stuff we really just dont know what the real deal is. And I think that it may boil down to some fairly unique individual considerations. But one thing that weve talked about on I think the standard podcast is when you look at what the recommendations are out of the Bernsteins Diabetes Solution. Its not specifically carnivores, but its a high protein, moderate fat, low carb diet.

Robb: And what this is specifically designed for our folks with type one diabetes And type one diabetes is so hard to manage because really the first activity of insulin when its released out of the beta cells of the pancreas, arguably is to downregulate glucagon in the adjacent alpha cells of the pancreas. And the way that type one diabetics have to manage this is completely in a reverse order of sticking insulin in at the surface exterior level and then waiting for it to fuse and get activity at the internal level.

Robb: And so they are not really fans of a really high fat Keto diet per se because it induces potentially physiological insulin resistance and people in it and it makes that management to blood glucose levels and the management of insulin boluses more challenging than a high protein, low carb, moderate fat intake, which looks really in a lot of ways a lot more like a carnivore approach.

Robb: When you get right down to it. So it makes sense to me to be more on that side of things. And then some of the early work that Loren Cordain did, one of his early papers, Paleo contemporary diet made from paleo food sources where he basically does a perspective to date 2000 calorie plan and it was for a woman and it was around 2100 calories a day, but it was over 200 grams of protein for a medium size female.

Robb: And then it was maybe like 150 grams of carbs and then, I dont know, 7,500 grams fat, something like that. But it was really high protein and so a lot of this stuff that Ive seen that comes out of the Keto games world, the Bernsteins Diabetes Solution, the people that seem to be succeeding on carnivore and also kind of that Loren Cordain perspective on paleo.

Robb: I just see a lot of similarities there. Mainly just this really powerful emphasis on protein. And then I think that we individually have to get in and do some tinkering, kind of figure out do I do okay with some plant material, do I have some gut issues that doesnt really allow for that. And then weve got some playing to deal with after that kind of kernel of like a very protein centric approach makes a ton of sense to me.

Ben: Yeah. I guess the other thing I would say is I kind of wonder if there is if the keto diet is kind of a myth in the sense of at least when I first started learning about it, I had the sense like when youre in a keto diet that means okay, my brain is being entirely told by ketose and then, so it was an interesting kind of happenstance that like when Im kind of measuring the ketones, its like theyre like in this middle range, theyre not that high.

Ben: And then I kind of was interested in seeing well how does that amount of ketones compare to glucose? And whats interesting is I guess a level of 80 what is it like milligrams per deciliter of glucose is around the ballpark of like 4.5 millimole per liter. So even when youre decently ketonic you still have-

Robb: A fair amount of glucose.

Ben: Three or maybe even four times as much glucose hanging around. So I, and maybe thats just the thing is like the Keto gains approach, which seems to work for me thats maybe not down-regulating things that you could still feel good on and do it sustainably just actually isnt really that much of a keto diet. And so whatever kind of secondary hormonal effect maybe there is a ketones is not really happening as far as down-regulating

Robb: Yeah, man its really interesting these things with potential thyroid downregulation and stuff like that. I do think that a decent whack of protein is going to produce enough of an insulin response that maybe that keeps you out of that thyroid down-regulated state. Maybe you dont need specifically a bolus of carbs to do it, particularly if youre eating something like beef or even Whitefish, which can produce a really remarkable insulin release.

Robb: And so maybe that is part of the reason why were not seeing that that keto gains seen just crumbling. Its mainly females and were not seeing a ton of HPA axis dysregulation or thyroid or hair falling out and stuff like that. They seem to be motoring along really well.

Robb: So it is interesting. Theres just some fascinating stuff on there. I forget who it was. Somebody recently was looking at the total energetic pool, which you just kind of alluded to of maybe about four to five millimolar glucose and then if we can get, usually ketone bodies are not remotely that high. Theyre people that are keto adapted. Actually were lucky if we get a much up over one, 1.5-

Ben: Oh, you know what, I have a question. So yeah, some of that I have been wondering and I couldnt find a quick answer on the internet part is like, okay, so how many, I mean I guess it depends on what level of ketosis youre at, but how many calories of ketones are you making in a day? Because I remember I used to be under the impression like, Oh you know, if I do like a shot of MCT oil, thats like all getting converted into ketones. But I dont think It doesnt seem to work like that.

Robb: Marty Kendall did a piece on this re I think it was Marty where it, and hes had just an interesting look on this. Basically making the case that somebody thats metabolically flexible and metabolically healthy at rest they have a comparatively low amount of circulating energy and that makes sense. You dont need a lot of glucose, you dont need a lot of triglycerides, you dont necessarily need a whole ton of ketone bodies.

Robb: You need enough but dont need a ton. And what we see on the flip side of people that are metabolically broken or heading into metabolic syndrome, theyve got high glucose, theyve got high triglycerides, the lifeboat proteins go up. And in really extreme cases we end up in a scenario in which we have ketoacidosis too. So were like drowning in energy in these situations of people with really poorly managed metabolic scenarios.

Robb: Now, and he did do some breakdown on the total energetic, not load, but I guess consequences of say like a given ketone level of in general MCTs is just kind of backing up a little bit. In general, my understanding is that MCTs do predominantly convert to ketone bodies. It is interesting on the brain metabolism side, it was only recently that they discovered that some medium chain fats, medium chain triglycerides can fuel the brain directly.

Robb: So the brain isnt only glucose or glucose and ketones like theres some medium chain fats in there and I dont know that anybodys really been looking at this, but under a more ketogenic scenario is the brain able to use longer chain fats? I dont know, but it was a surprise that it could use medium chain triglycerides.

Robb: So I wouldnt be shocked if we had another surprise that theres some utilization of longer chain fats in addition to the ketone body. Interesting thing is the production of ketones is kind of thermodynamically inefficient. Theres an energy loss in that whole story. And so biology wouldnt be super stoked about that. Its great on the one hand from kind of a potential fat loss perspective, although youre talking about maybe 25, 50 calories a day. I mean if you miscalculate your handful of almonds, you just screwed that quote metabolic advantage up.

Ben: Hold on I wonder though, I mean is the conversion of the MCT into beta hydroxy iterate? Is that actually that much more energy costly then like a longer chain fatty acid that going through everything to get converted into acetol COA. I mean take one more step.

Robb: Its a little bit more energetically costly and its both good and bad because youre popping out of the NADH part of this story and relying more on the FADH part of the story. Youre pulling things away from going through the mitochondrial complexes one, three and five.

Robb: Theyre more mitochondrial complex too, which has a lower oxidative stress but interestingly is a little bit more energetically demanding. So, and again at the end of the day, I dont know how much any of that matters in the big picture, but its interesting stuff for sure.

Ben: Yeah, you definitely hear a lot of, I mean at least when I was first getting into this stuff, you get sold on this idea fat it burned so much cleaner. You almost get this visual, if you dont know Biochem that literally like the electrons or whatever the hell is getting stripped directly off the fat.

Ben: But at the end of the day its just like a Acetyl-CoA really. And you kind of like DC whatever differences that there are just marginal or really just marginal and but it adds up I guess on a big scale

Robb: It could. Nickys going to cut us off here because were getting long winded but couple of quick thoughts. So it is just that clearly for at least some people, a low carb or ketogenic approach, whether carnivores or whatever. It just offers some really remarkable appetite control, youre just not hungry in the same way that you were on kind of a mixed diet.

Robb: And thats a huge win. And I would say that 90, 95% of the benefit is there. When we look at longevity research in animals, most of the benefit of calorie restriction seems to just be that theyre being protected from a super shitty lab, chow based diet. And when animals are fed a species appropriate diet, you dont really see much benefit, but it may be even detriment for a species appropriate diet.

Robb: So I, if we figure out a way to just not succumb to overeating in the modern industrial world, and I think thats like 90 or 95% of the fight and then from there, this 5% of do we have H stack inhibition? Do we have lower oxidative stress? There might be truth to that, but I think all of that takes kind of second seat to just the fact that were not overeating.

Nicki: Thanks Ben for your call.

Robb: Nicki is doing the big hook-

Ben: Thanks for answering my call.

Robb: -and yanking us out of here.

Nicki: Thanks so much.

Robb: Take care man.

Ben: Thank you, you too.

Robb: Bye, bye.

Ben: Bye

Nicki: Welcome to The Healthy Rebellion Radio. Can you tell us your name and where youre calling from and your question?

Zach: Hey, its Zach from Reno. Missed you guys.

Nicki: Hey Zach. How are you doing?

Zach: Doing great. How are you doing?

Robb: Good.

Nicki: Great. What can we answer for you today?

Zach: Okay. Can you hear me okay? Im kind of outside right now.

Nicki: Yeah.

Robb: Youre coming through? Yep.

Zach: Okay, cool. First off, I just want to thank you for that interview do with a doctor Saladino, did I pronounce that right?

Robb: Yep.

Zach: Yeah, I didnt know the damn, I mean like your other books, youve kind of talked about your struggles, but hearing the full extent, I was like, Oh man, I make a lot of excuses. So I really appreciate you leading by example and being transparent about all that.

Robb: Thank you.

Zach: Basically my question is I have a lot of behaviors Ive used over the years to varying degrees of being unhelpful. So like when we put one behavior and we do kind of this stereotypical cross eviction type thing where we use another behavior. Im kind of curious as to what methods you use outside of working on mindset, movement, sleep, wake cycle, like all the general things.

Zach: Have you guys gone down the amino acid rabbit hole? Its like brain support or have you seen other ways of trying to change multiple behaviors at the same time?

Robb: Man, Ive done a fair amount of tinkering with the amino acid story. I personally havent had great success with it. A good friend of mine, Dr Ben Bolser leans heavily on that and but also its in the context of kind of appropriate glycaemic load, paleo West type diet. And so I think that for some people doing DL phenol alanine can really dramatically increase dopamine levels in either depression or chronic pain.

Robb: It can really help with that. But on facilitating that behavior change. And its a really interesting thing going from one kind of addictive behavior to another within CrossFit, and this isnt beating up on CrossFit, but within CrossFit there are a remarkable number of former addicts from alcohol to harder drugs. And you could make the case that they kind of supplanted one addiction with another.

Robb: And then depending on to what degree CrossFit takes over their life, it may take on some maladaptive characteristics. But I guess Im a little bit sanguine on that in the I think that so long as we figure out something that seems like a better option than maybe thats a good idea.

Robb: But I did in my youth, I lived literally next door to a methadone clinic and those folks would chain smoke and eat Twinkies like their life depended on it and I dont it clearly compared to heroin. Maybe theyve got a longer run on the Twinkie and cigarette diet than they were on the black tar heroin diet.

Robb: But at the same time thats going to have an expiration date on it too. So man, I dont know as far as it is definitely outside my wheelhouse on that. That definitely gets into the addiction counseling and stuff like that, which I am not even remotely well steeped in. But again, I guess circling back to your original question, Ive tinkered with some of the amino acid stuff, recommending things like tyrasine or tryptophan at various points and they I havent seen it work miracles for me.

Robb: But again, Im also not at an exceptionally well schooled in the protocols on that stuff. I do know some people really, they profess some really remarkable successes with that. But I think beyond addressing sleep quality and things like that. Its hard to beat those elements and then even some things like some degree of sleep deprivation that feeds into consolidating sleep into a more sleep efficient period.

Robb: Theyve used that for some bipolar disorder and some depression. So I think tweaking the levers of circadian biology, sleep and food in my opinion are probably more powerful tools or that shows the confirmation bias of my limited experience on that.

Zach: Yeah, no, I appreciate that. It sounds funny but I mean even having read about this stuff for over 10 years, it took me until last year to accept how bad my sleep has been. For literally decades. How a natural extent and going through some really good, well reputable, clean books and how it talks about kind of what you were just saying, how having that chronic sleep deprivation can impact decision making and all these other things.

Zach: Your brain is basically damaged to varying levels on a daily basis. So, okay. I appreciate that feedback and I really appreciate the healthy rebellion. So thank you very much.

Robb: Awesome man.

Nicki: Thanks Zach.

Robb: Take care. And we miss all of our peeps in Reno.

Nicki: Yeah, take care.

Zach: Yeah, you too. I missed being crushed by you a regular bases.

Robb: Well, well see you at a Spring Camp. Take care, man.

Zach: Awesome, thanks brother. Have a good day. Bye.

Nicki: All right. Our final question this week is in written format and its from Nate on the dangers of Stevia. He says, Hi Robb and Nicki. Huge fan of the show and format. Do you see any dangers in consuming pure Stevia powder or liquid other than the obvious danger of it potentially making you crave more sweeter foods?

Nicki: Have you read about any credible downsides to it that would concern you? I love the stuff. It helps me on my keto diet and I just want to make sure its cool to keep consuming in moderation. About a quarter to a half teaspoon, maybe a day. Thanks again for being an unbiased source of truth in this crazy landscape.

Robb: Well, I dont know if Im unbiased. Everybody has a bias. I appreciate the vote of confidence. Hopefully my bias being steeped in evolutionary biology and a little bit of biochemistry and stuff. Hopefully that gives us a half decent place to at least start the conversation around.

Robb: But the stevia and sweetener topic, its funny, particularly within fasting circles, people will see Stevia say in the element product that we have and they freak out and theyre like, it stops your blancher fast. And Im like, via what mechanism?

Robb: And then theres radio silence and then Im a big mean person because Im being a scientific or whatever, I dont even know. But so people will make cases around, well you release insulin and I think in some people under some circumstances, typically in an overfed state, stevia could pose a problem because its an additional sweetening agent.

Robb: But the interesting thing with it is it lowers blood sugar, which they usually hold up as being a laudable thing. But that is because it gooses a little release of insulin, but its not a really huge amount under the conditions of keto and fasting. It is trivial, non-significant, or maybe even beneficial because youre actually scooting a little bit of blood glucose into storage and then youre going to burn fat and produce ketones more.

Robb: So even on that whole autophagy side, Ive been digging around and theres not a ton of material around this, but stevia, lice, like most plant materials seems to enhance certain degrees of autophagy. So again, in the, what was his name?

Nicki: Nate.

Robb: Nate, hit the nail on the head, the real concern around any type of modified sweetener flavoring in something like chicharrones, if theyre plain, youll have one or two and youre good. If they have like-

Nicki: Barbecue flavor.

Robb: Barbecue flavor then youll have one or two bags. And so thats where we get into hazards mainly with these different flavors and sweeteners and stuff.

Nicki: Making it hyper palatable and-

Robb: Making it hyper palatable. People get all wrapped around the axle of, well, its got a little bit of monosodium glutamate or this or that, either the other. And its like thats really not the issue generally other than maybe some very sensitive people.

Robb: But the issue is when we tweak things in such a way that we can easily overeat them. We were messing around with a couple of different chocolate bar variations and theyre pretty good. Theyre mainly stevia sweetened and then we found this one and Oh my God, its like amazing.

Nicki: Yeah, it was like a zero. It was like a sugar free chocolate bar, but it also had almonds in it and I saw that it changes the palette.

Robb: Just the mouth feel though, and like man, it tastes like chocolate. And this is something where normally the standard like stevia sweetened chocolate bars-

Nicki: 80% chocolate.

Robb: Well eat a piece or two and its no big deal. But we would through the course of a day, smash.

Nicki: The entire bar.

Robb: At least one bar, maybe more if it was around.

Nicki: So we had to stop buying those.

Robb: Just dont last that much. Yeah. Those are examples. But the problem is the hyper palatability thing that occurs, in my opinion, not necessarily that these specific sweeteners are in and of themselves problematic.

Nicki: Awesome. Thanks for the great question, Nate. All right, thats a wrap. And then thank you for joining us. Make sure to check out our show sponsor Perfect Keto for all your keto needs. You can go to perfectketo.com/rebellion10 and use code REBELLION10 for $10 off your order of $40 or more. Please-

Robb: Share this episode.

Nicki: Share this episode.

Robb: If you enjoy it. If you find it helpful-

Nicki: You can help us.

Robb: Share this thing around.

Nicki: Reach our mission of getting a million people out of the sick care system by spreading this podcast. We are doing all that we can to get the message of health out there in regenerative agriculture and the fact that we have power over how we feel and how our bodies are.

Robb: Its profound in its profundity, but seriously that weve had solid growth, but to reach this goal of getting a million people out of the sick care system, we need yalls help and the feedback that we get is that the shows awesome. We produce good content. Its super helpful, but we need to start sharing this out to the masses and clearly the show isnt going to be a perfect fit for everybody, but if somebody has-

Nicki: Especially with you F-bomb.

Robb: Particularly with my F-bombs.

Nicki: Tendency.

Robb: But if you know somebody that is struggling and they have a certain health issue or a certain question, its a pretty good chance that weve covered it at some point in either this show or a previous show. So please do share that stuff around. Sign up for this subscription.

Nicki: And if you want to join us in the healthy rebellion community where I guess when this show airs, were just wrapping up our first 30 day reset and 7 day carb test.

Robb: Which has gone amazing.

Nicki: We couldnt be happier. People are making some great strides, breakthroughs. Weve had mindset coaches come in where its been a really, really special experience. So were looking to do more stuff like that. But this just the community in general, its a really amazing place and weve got some great people and wed love to have you as well. So you can go to join.thehealthyrebellion.com and well see you in there.

Robb: Awesome. Thank you wife.

Nicki: Thanks hubs.

Robb: See yall soon.

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